I have the same issue with the wife and scrolling on web pages.
You say "scroll down" to her and the page goes UP. I don't get it......
Have you tried Mac OS X? Apple reversed the directional effect of the mouse scroll wheel, a few versions ago. Called it 'natural scroll' iirc. Natural or not is a matter of opinion (I say 'not'), but it's totally alien to anybody who was already used to a mouse.
Now, whenever one installs OS X the head scratching begins 'Where is the setting to fix the scrolling direction?'.