The situation is connected to that part of IE8 which is "SmartScreenFilter" which holds a form of Hosts File all of it's own, and Spybot s+D and SpywareBlaster immunization features are conflicting with that.
Although SmartScreenFilter can be disabled, the "hostfile" remains.
The recommendation is that the SmartScreenFilter offers more protection than Spybot or SpywareBlaster, and that these two progs should be uninstalled.