Thanks to both for the interest and suggestions.
@jelv:
Regarding clicking the scroll wheel, this still works on the wired mouse bringing up the circular up/down icon and invoking scrolling action, does not currently work on the wireless mouse.
This action appears to behaves normally on the wired mouse anyway and although not working on the wireless mouse, completely disabling this does not cure the issue.
@Ronski:
Have read the 2 references supplied, not exactly my symptoms but possibly relevant.
Checked the registery entry mentioned and as expected this value is still set at the default value of 3.
Will try to explain my symptoms in more detail.
As well as the scrolling issues any open window such as DSLStats opened within a VNC Viewer window which has selection or pull down tabs, hovering the mouse cursor over any tab (before actually selecting) causes a rapid transition through all the tabs which only stops when the mouse cursor is moved away to a clear screen area making it impossible to accurately select any tab.
Yet, selecting file explorer within the same VNC viewer window behaves completely to expectation with respect to mouse operation.
I get the same effect with my Swann CCTV PC viewer utility making it impossible to select any of the pull down options, this is where I first noticed the anomaly yesterday.
In Win device manager I have 2 HID-compliant mouse entries for some reason, appear identical, a third entry appears when I plug in my USB wired mouse.
Have tried deleting both mouse entries, having to then plug in the USB mouse to exit, on re-booting both "HID-complient mouse" entries have re-appeared.
My desktop PC was running all day yesterday when the anomaly first presented.
No Win updates or otherwise logged, I always configure updates to notify before installing where possible.
No changes made or new programs installed, PC was unattended most of the day.
Now, even more strange, booted up this morning and mouse action is completely normal !
Wondering if I should perform the registery edit as suggested and/or try to get rid of one of the "HID-complient mouse" entries ?
Perhaps just leave things alone while all well ?