It can greatly depend on the powerline adaptors you use as to whether any noticeable interference is seen. For example, I've been using a pair of D-Link AV200 (DHP-306AVs) to bridge upstairs with downstairs for many years and these don't cause any additional interference in my home (my error rate remains pretty constant with or without them connected at ~300 CRC errors per hour). Whilst they're not the fastest units, at the time they were much easier than running in network cable and have proved much more reliable than wireless.
More recently I attempted to replace them with the AV500 units from Zyxel. After a few hours of them being connected I'd seen that my line had become interleaved, lost several Mb of downstream speed and was showing many millions of FEC errors every 15 minutes. Whether the homeplugs were in use or not was irrelevant - the interference was there to see regardless. Disconnecting them, the line stats returned to sensible values, so I swapped my original AV200 adapters back in. Until interleaving was removed from my line, which took about 2 months, the modem was reporting about 10,000 FEC errors every 15 minutes.
I don't know if the interference was caused by the higher bandwidth signalling in the AV500 specification or by poor noise suppression in the adapters. Other brands of AV500 units may fair differently but I'm planning to eventually replace my AV200 adapters with network cable as and when I get time.