There are several new nasties around that are catching people out and preventing removal as they are replicated or triggered by users natural reponse to reboot and try to reach safe mode.
Win7 Antivirus is seeded all over the net , Facebook is a known source of infection, this malware also is often packaged with other infections and will often prevent even the best AV /Antimalware systems running and preventing removal.
DO NOT shut down/reboot your machine, Rkill a tool available from Bleeping Computers could well rescue your system, download and run this tool THEN use your normal AV system or malware tool to clear the infection.
What Rkill is and does (and does not ) do
http://www.bleepingcomputer.com/forums/topic308364.html Rkill downloads
http://www.bleepingcomputer.com/download/anti-virus/rkillrkill comes in various package names, this is because the malware writers know about the tool and include code to prevent download/install/run, keep trying a package till you find one that works.