I use Acronis to back up to my server, and then on my server I have Crash Plan that backs up to the cloud. Hopefully this will at least give me access to fairly recent copies of my data.
Acronis does a full backup of my C drive once a month, and a backup of the users folder every two weeks. Any users folders stored on the server are backed up in real time.
Of course the only problem with this is how long it will take to get the data back, even though I have fibre I doubt a download from Crash Plan will max my connection out. The bulk of my data won't be urgently needed though, so not a major problem. As a backup to that I do have a couple of hard drives stored off site that have a lot of stuff backed up to them, but I tend to forget to do that regularly - hence why I started using crash plan.
Oh, and all my PC's have the WHS2011 backups done daily, but last time I tried to restore one of them it didn't :-(
I also use Dropbox for some stuff that I'm working on, like the code for the logging GUI. Although anything in Dropbox would be affected by CryptoLocker, there are the previous versions, which are available for 30 days.