I do and have done for a long time.
It does automatic updates of whatever needs to be updated (program or definitions etc) every 15 minutes
It WAS a memory/performance hog in the mid 2000's but since then it was totally re-written as I recall and now I do not notice it on my PC at all when it is doing either its quick or full scans or its downloads/updates.
I have never had any nasties on my computer though Norton has blocked me from visiting some websites where it found something unpleasant on them and has blocked a couple of downloads of programs recommended on a UK techie forum as they we deemed to contain PUP's within the installer.
I also use the PC for business purposes and social club type stuff storing on it personal details so it is pretty well a business insurance compliance requirement to be able to show that you have a 'paid for' constantly updated full internet security suite on your computers.